Publications
Click here to view all of Dr. Bear's publications on PubMed.
Click here to view Bear Lab students' Ph.D. Theses (Restricted Access)
2020 - Present
Electrophysiological signatures of visual recognition memory across all layers of mouse V1. bioRxiv. Pre-print 2023 January 25
Metaplasticity: a key to visual recovery from amblyopia in adulthood? Current Opinions in Ophthamology. 2022 November 1
Partial Recovery of Amblyopia After Fellow Eye Ischemic Optic Neuropathy. Journal of Neuroophthamology. Epub 2022 June 23
Stimulus-Selective Response Plasticity in Primary Visual Cortex: Progress and Puzzles Frontiers in Neural Circuits. 2022 January 31
mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence Frontiers in Psychiatry. 2021 September 29
The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity Current Biology. 2021 September 27
Correction of amblyopia in cats and mice after the critical period eLife. 2021 August 31
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain Cell Reports. 2021 July 6
Visual recognition is heralded by shifts in local field potential oscillations and inhibitory networks in primary visual cortex Journal of Neuroscience. 2021 June 7
Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice Molecular Psychiatry. 2020 July 1
Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator Neuron. 2020 Jun 25
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome Sci Transl Med. 2020 May 20
Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice Mol Cells. 2020 Apr 30
Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity Cereb Cortex. 2020 Apr 14
Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex Front Cell Neurosci. 2020 Jan 14
2010 - 2019
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome Science Translational Medicine. 2019 May 29
In memoriam: John Lisman - commentaries on CaMKII as a memory molecule. Molecular Brain. 2018 Dec 28
The mouse as a model for neuropsychiatric drug development. Current Biology. 2018 Sep 10
Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline. J Neurosci. 2018 Sep 26.
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat Rev Drug Discov. 2017 Dec 8.
Recovery from the anatomical effects of long-term monocular deprivation in cat lateral geniculate nucleus. J Comp Neurol. 2017 Oct 11. [Epub ahead of print]
R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice. Neuropsychopharmacology. 2017 Oct 6. [Epub ahead of print]
Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1. J Neurosci. 2017 Sep 26. [Epub ahead of print]
Arc restores juvenile plasticity in adult mouse visual cortex. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9182-9187
Arbaclofen in fragile X syndrome: results of phase 3 trials. J Neurodev Disord. 2017 Jun 12;9:3. eCollection 2017
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Rep. 2017 Mar 21;18(12):2807-2814
Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome. J Neurosci. 2016 Nov 23;36(47):11946-11958
Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures. Mol Autism. 2015 Dec 21;6:66
Convergence of Hippocampal Pathophysiology in Syngap(+/-) and Fmr1(-/y) Mice. J Neurosci. 2015 Nov 11;35(45):15073-81
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7
Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Hum Mol Genet. 2015 Nov 1;24(21):5977-84
Visual recognition memory: a view from V1. Curr Opin Neurobiol. 2015 Jul 4;35:57-65
Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1. Nat Neurosci. 2015 Feb;18(2):262-71
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nat Neurosci. 2015 Feb;18(2):182-4
Extinction of an instrumental response: A cognitive behavioral assay in Fmr1 knockout mice. Genes Brain Behav. 2014 Jun;13(5):451-8
Learned spatiotemporal sequence recognition and prediction in primary visual cortex. Nat Neurosci. 2014 May;17(5):732-7
Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Mol Autism. 2014 Feb 24;5(1):16
How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130284
STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study. J Autism Dev Disord. 2014 Apr;44(4):958-64
Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Mol Autism. 2013 May 24;4(1):15
Fragile X mental retardation protein and synaptic plasticity. Mol Brain. 2013 Apr 8;6:15
A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex. Neuron. 2013 Feb 20;77(4):723-35
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile x syndrome. Neuron. 2013 Jan 23;77(2):243-50
Lifting the Mood on Treating Fragile X. Biol Psychiatry. 2012 Dec 1;72(11):895-7
The BCM theory of synapse modification at 30: interaction of theory with experiment. Nat Rev Neurosci. 2012 Nov;13(11):798-810
Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen. Sci Transl Med. 2012 Sep 19;4(152):152ra128
Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial. Sci Transl Med. 2012 Sep 19;4(152):152ra127
Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice. Neuron. 2012 Apr 12;74(1):49-56
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci. 2012;35:417-43 Epub 2012 Apr 5
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). Review
Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature. 2011 Nov 23;480(7375):63-68
A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1266-74
Stimulus-Selective Response Plasticity in the Visual Cortex: An Assay for the Assessment of Pathophysiology and Treatment of Cognitive Impairment Associated with Psychiatric Disorders. Biol Psychiatry. 2012 Mar 15;71(6):487-95
Translating glutamate: from pathophysiology to treatment. Sci Transl Med. 2011 Sep 28;3(102):102mr2
New views of Arc, a master regulator of synaptic plasticity. Nat Neurosci. 2011 Mar;14(3):279-84
Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2587-92
Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex. J Neurosci. 2010 Dec 1;30(48):16304-13
Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome. Annu Rev Med. 2011;62:411-29
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome. J Neurosci. 2010 Nov 17;30(46):15616-27
Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment. Brain Res. 2011 Mar 22;1380:106-19
Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex. J Neurosci. 2010 Jul 21;30(29):9670-82
Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions. Front Cell Neurosci. 2010 Jun 17;4:21
Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis. J Neurophysiol. 2010 Aug;104(2):1047-51
Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex. Neuron. 2010 May 27;66(4):493-500
Mechanism-based approaches to treating fragile X. Pharmacol Ther. 2010 Jul;127(1):78-93
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation. Nat Neurosci. 2010 Apr;13(4):450-7
Promoting neurological recovery of function via metaplasticity. Future Neurol. 2010 Jan 1;5(1):21-26
Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons. J Mol Neurosci. 2010 Sep;42(1):1-8
2000 - 2009
The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial J Neurol. 2009 Jul;256(7):1095-102
The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation Neurobiol Learn Mem. 2009 Jul;92(1):106-13
Anatomical origins of ocular dominance in mouse primary visual cortex Neuroscience. 2009 Jun 30;161(2):561-71
Essential role for a long-term depression mechanism in ocular dominance plasticity Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9860-5
Learning reward timing in cortex through reward dependent expression of synaptic plasticity Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6826-31
Thalamic activity that drives visual cortical plasticity Nat Neurosci. 2009 Apr;12(4):390-2
The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5377-82
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67
Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation Biochem Biophys Res Commun. 2008 Dec 19;377(3):930-4
The autistic neuron: troubled translation? Cell. 2008 Oct 31;135(3):401-6
Recovery from monocular deprivation using binocular deprivation J Neurophysiol. 2008 Oct;100(4):2217-24
Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex Neuron. 2008 May 8;58(3):340-5
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome J Physiol. 2008 Mar 15;586(6):1503-8
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1 J Neurosci. 2008 Feb 13;28(7):1697-708
Fragile X: translation in action Neuropsychopharmacology. 2008 Jan;33(1):84-7
Correction of fragile X syndrome in mice Neuron. 2007 Dec 20;56(6):955-62
Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? Mol Neurobiol. 2007 Jun;35(3):298-307
Obligatory Role of NR2A for Metaplasticity in Visual Cortex Neuron. 2007 Feb 15;53(4):495-502
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1383-8
Learning induces long-term potentiation in the hippocampus Science. 2006 Aug 25;313(5790):1093-7
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression Neuropharmacology, 2007 Jan; 52(1): 71-6
Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex Neuropharmacology 2007 Jan; 52(1): 200-14
Instructive effect of visual experience in mouse visual cortex Neuron. 2006 Aug 3;51(3):339-49
Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats J Neurosci. 2006 Jul 12;26(28):7368-74
The Stimulus for Rapid Ocular Dominance Plasticity in Visual Cortex J Neurophysiol. 2006 May; 95(5): 2947-50
Reward timing in the primary visual cortex Science. 2006 Mar 17;311(5767):1606-9
Therapeutic implications of the mGluR theory of fragile X mental retardation Genes Brain Behav. 2005 Aug;4(6):393-8
Courting a cure for fragile X Neuron. 2005 Mar 3;45(5):642-4
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression J Biol Chem. 2005 Apr 29;280(17):16962-8
How monocular deprivation shifts ocular dominance in visual cortex of young mice Neuron. 2004 Dec 16;44(6):917-23
LTP and LTD: an embarrassment of riches Neuron. 2004 Sep 30;44(1):5-21
A morphological correlate of synaptic scaling in visual cortex J. Neurosci. 2004 Aug; 24(31):6928-6938
The mGluR theory of fragile x mental retardation Trends in Neuroscience 2004 Jul; 27(7): 370-377
Significance of N-methyl-D-(NMDA) receptor-mediated signaling in human keratinocytes J. Cellular Physiology 2004 Aug; 200(2):309-17
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1 J Neurosci. 2004 May 19; 24(20):4859-64
Segmentation of coarse and fine scale features using multi-scale diffusion and Mumford-Shah Lecture Notes in Computer Science. 2003;2695:615-624
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression Neuron. 2003 Oct 30;40(3):595-607
Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation Nat Neurosci. 2003 Aug;6(8):854-862
NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex Neuron. 2003 Jun 19;38(6):977-85
Bidirectional synaptic plasticity: from theory to reality Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):649-55
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity Proc Natl Acad Sci U S A. 2002 Jul 22
Altered synaptic plasticity in a mouse model of fragile X mental retardation Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
Synaptic plasticity in an altered state Neuron. 2002 Feb 28;33(5):665-7
Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo J Neurosci. 2001 Dec 15;21(24):9801-13
A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons J Neurosci. 2001 Dec 15;21(24):9541-8
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory Cell. 2001 Nov 30;107(5):617-29
Internalization of ionotropic glutamate receptors in response to mGluR activation Nat Neurosci. 2001 Nov;4(11):1079-85
Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex Neuropharmacology. 2001 Nov;41(6):762-70
Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10924-9
Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex J Neurosci. 2001 Sep 1;21(17):6791-801
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1 J Neurophysiol. 2001 Jul;86(1):321-5
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex Neuron. 2001 Jan;29(1):157-69. Shouval HZ, Bear MF, Cooper LN
Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo Neuron. 2000 Nov;28(2):527-36
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity Nature. 2000 Jun 22;405(6789):955-9
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression Science. 2000 May 19;288(5469):1254-7
1990-1999
Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors J Neurophysiol. 1999 Dec;82(6):3594-7
Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12876-80
Molecular basis for induction of ocular dominance plasticity J Neurobiol. 1999 Oct;41(1):83-91
BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex Cell. 1999 Sep 17;98(6):739-55
Homosynaptic long-term depression: a mechanism for memory? Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9457-8
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo Nat Neurosci. 1999 Apr;2(4):352-7
A molecular correlate of memory and amnesia in the hippocampus Nat Neurosci. 1999 Apr;2(4):309-10
Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine J Neurosci. 1999 Mar 1;19(5):1599-609
Monocular deprivation induces homosynaptic long-term depression in visual cortex Nature. 1999 Jan 28;397(6717):347-50
Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression Neuron. 1998 Nov;21(5):1163-75
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus Neuron. 1998 Nov;21(5):1151-62
Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex Neuropharmacology. 1998 Apr-May;37(4-5):571-9
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex J Neurosci. 1998 Jan 1;18(1):1-9
Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3380-3
How do memories leave their mark? Nature. 1997 Feb 6;385(6616):481-2
A synaptic basis for memory storage in the cerebral cortex Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13453-9
A current source density analysis of evoked responses in slices of adult rat visual cortex: implications for the regulation of long-term potentiation Cereb Cortex. 1996 Nov-Dec;6(6):751-8
Experience-dependent modification of synaptic plasticity in visual cortex Nature. 1996 Jun 6;381(6582):526-8
Bidirectional modification of CA1 synapses in the adult hippocampus in vivo Nature. 1996 May 9;381(6578):163-6
Metaplasticity: the plasticity of synaptic plasticity Trends Neurosci. 1996 Apr;19(4):126-30
Progress in understanding NMDA-receptor-dependent synaptic plasticity in the visual cortex J Physiol Paris. 1996;90(3-4):223-7
NMDA-receptor-dependent synaptic plasticity in the visual cortex Prog Brain Res. 1996;108:205-18
Long-term depression in hippocampus Annu Rev Neurosci. 1996;19:437-62
Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat Learn Mem. 1996 Nov-Dec;3(4):313-25
Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation J Neurophysiol. 1995 Sep;74(3):1075-82
Mechanism for a sliding synaptic modification threshold Neuron. 1995 Jul;15(1):1-4
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience Nature. 1995 May 25;375 (6529):328-31
Elementary forms of synaptic plasticity in the visual cortex Biol Res. 1995;28(1):73-80
Synaptic plasticity: LTP and LTD Curr Opin Neurobiol. 1994 Jun;4(3):389-99
Homosynaptic long-term depression in the visual cortex J Neurosci. 1994 May;14(5 Pt 2):3404-12
A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3941-5
Hebbian synapses in visual cortex J Neurosci. 1994 Mar;14(3 Pt 2):1634-45
Role of the visual environment in the formation of receptive fields according to the BCM theory Prog Brain Res. 1994;102:287-301
Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus J Neurosci. 1993 Jul;13(7):2910-8
Common forms of synaptic plasticity in the hippocampus and neocortex in vitro Science. 1993 Jun 4;260(5113):1518-21
Neocortical long-term potentiation Curr Opin Neurobiol. 1993 Apr;3(2):197-202
Effects of N-methyl-D-aspartate on quisqualate-stimulated phosphoinositide hydrolysis in slices of kitten striate cortex Brain Res. 1992 Oct 23;594(1):146-9
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade Proc Natl Acad Sci U S A. 1992 May 15;89(10):4363-7
Long-term potentiation in slices of kitten visual cortex and the effects of NMDA receptor blockade J Neurophysiol. 1992 Apr;67(4):841-51
Synaptic plasticity in visual cortex: comparison of theory with experiment J Neurophysiol. 1991 Nov;66(5):1785-804
Learning and memory. FESN Study Group Brain Res Brain Res Rev. 1991 May-Aug;16(2):193-220
Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex Exp Brain Res. 1991;85(3):611-5
Stimulation of phosphoinositide turnover by excitatory amino acids: Pharmacology, development, and role in visual cortical plasticity Ann N Y Acad Sci. 1991;627:42-56
Binocular competition in the control of geniculate cell size depends upon visual cortical N-methyl-D-aspartate receptor activation Proc Natl Acad Sci U S A. 1990 Dec;87(23):9246-9
Basal forebrain projections to somatosensory cortex in the cat J Neurophysiol. 1990 Oct;64(4):1223-32
Cholinergic manipulation alters stimulus-evoked metabolic activity in cat somatosensory cortex J Comp Neurol. 1990 Jul 1;297(1):106-20
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist J Neurosci. 1990 Mar;10(3):909-25
N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro Exp Brain Res. 1990;80(2):252-9
1980 - 1989
A biochemical correlate of the critical period for synaptic modification in the visual cortex Science. 1989 Nov 3;246(4930):673-5
Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation Brain Res Dev Brain Res. 1989 Jun 1;47(2):281-8
Visual experience regulates gene expression in the developing striate cortex Proc Natl Acad Sci U S A. 1989 Jun;86(12):4781-4
Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes Brain Res Dev Brain Res. 1989 May 1;47(1):123-8
Experience-dependent modifications of kitten striate cortex are not prevented by thalamic lesions that include the intralaminar nuclei Exp Brain Res. 1988;70(3):627-31
Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex Science. 1987 Oct 16;238(4825):355-8
A physiological basis for a theory of synapse modification Science. 1987 Jul 3;237(4810):42-8
Modulation of visual cortical plasticity by acetylcholine and noradrenaline Nature. 1986 Mar 13-19;320(6058):172-6
Postnatal changes in the distribution of acetylcholinesterase in kitten striate cortex J Comp Neurol. 1985 Jul 22;237(4):519-32
Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens J Neurosci. 1985 May;5(5):1262-75
Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain Brain Res. 1985 Apr 29;333(1):165-8
An investigation of cholinergic circuitry in cat striate cortex using acetylcholinesterase histochemistry J Comp Neurol. 1985 Apr 22;234(4):411-30
The stability of 6-hydroxydopamine under minipump conditions Exp Brain Res. 1984;56(1):183-6
Somatostatin-like immunoreactivity in the forebrain of Pseudemys turtles Neuroscience. 1983 Jun; 9(2):297-307
Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity Nature. 1983 Mar 17-23;302(5905):245-7
The plastic response to monocular deprivation persists in kitten visual cortex after chronic depletion of norepinephrine J Neurosci. 1983 Feb;3(2):407-16
The laminar organization of the reciprocal projections between the claustrum and striate cortex in the tree shrew, Tupaia gli Brain Res. 1980 Feb 17;184(1):193-8