Publications
Click here to view all of Dr. Bear’s publications on PubMed.
Click here to view Bear Lab students’ Ph.D. Theses on MIT DSpace (Restricted Access)
2020 – PRESENT
Barnes SA, Thomazeau A, Finnie PSB, Heinrich MJ, Heynen AJ, Komiyama NH, Grant SGN, Menniti FS, Osterweil EK, Bear MF. Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus. Cell Rep. 2025 Feb 16
Montgomery DP, Bowen DA, Wu J, Bear MF, Gaier ED. Cortical responses to conflicting binocular stimuli in mouse primary visual cortex. bioRxiv [Preprint]. 2025 Jan 1
Fink JJ, Delaney-Busch N, Dawes R, Nanou E, Folts C, Harikrishnan K, Hempel C, Upadhyay H, Nguyen T, Shroff H, Stoppel D, Ryan SJ, Jacques J, Grooms J, Berry-Kravis E, Bear MF, Williams LA, Gerber D, Bunnage M, Furey B, Dempsey GT. Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype. Commun Biol. 2024 November 6
De Jesús-Cortés H, Cramer TLM, Bowen DA, Reilly-Andújar F, Lu S, Gaier ED, Bear MF. Using the visual cliff and pole descent assays to detect binocular disruption in mice. bioRxiv [Preprint]. 2024 September 25
Echavarri-Leet MP, Resnick HH, Bowen DA, Goss D, Bear MF, Gaier ED. Spontaneous recovery from amblyopia following fellow eye vision loss: a systematic review and narrative synthesis. JAAPOS. 2024 August 28
Gaier ED, Bear MF. Comments on: Partial Recovery of Amblyopia After Fellow Eye Ischemic Optic Neuropathy: Response. Journal of Neuroophthamology. 2024 March 1
Duffy KR, Bear MF, Patel NB, Das VE, Tychsen L. Human deprivation amblyopia: treatment insights from animal models. Frontiers in Neuroscience. 2023 September 19
Echavarri-Leet MP, Resnick HH, Bowen DA, Goss D, Bear MF, Gaier ED. Recovery from Amblyopia in Adulthood: A Meta-Analysis. medRxiv. Pre-print 2023 May 28
Duffy KR, Crowder NA, Heynen AJ, Bear MF. Comparative analysis of structural modifications induced by monocular retinal inactivation and monocular deprivation in the developing cat lateral geniculate nucleus. Journal of Comparative Neurology. Epub 2023 May 3
Hayden DJ, Finnie PSB, Thomazeau A, Li AY, Cooke SF, Bear MF. Electrophysiological signatures of visual recognition memory across all layers of mouse V1. bioRxiv. Pre-print 2023 January 25; Journal of Neuroscience, 2023 September 15
Leet MP, Bear MF, Gaier ED. Metaplasticity: a key to visual recovery from amblyopia in adulthood? Current Opinions in Ophthamology. 2022 November 1
Resnick HH, Bear MF, Gaier ED. Partial Recovery of Amblyopia After Fellow Eye Ischemic Optic Neuropathy. Journal of Neuroophthamology. Epub 2022 June 23
Montgomery DP, Hayden DJ, Chaloner FA, Cooke SF, Bear MF. Stimulus-Selective Response Plasticity in Primary Visual Cortex: Progress and Puzzles Frontiers in Neural Circuits. 2022 January 31
Stoppel DC, McCamphill PK, Senter RK, Heynen AJ, Bear MF. mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence Frontiers in Psychiatry. 2021 September 29
Finnie PSB, Komorowski RW, Bear MF. The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity Current Biology. 2021 September 27
Fong MF, Duffy KR, Leet MP, Candler CT, Bear MF. Correction of amblyopia in cats and mice after the critical period eLife. 2021 August 31
Venturino A, Schulz R, De Jesús-Cortés H, Maes ME, Nagy B, Reilly-Andújar F, Colombo G, Cubero RJA, Uiterkamp FES, Bear MF, Siegert S. Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain Cell Reports. 2021 July 6
Hayden DJ, Montgomery DP, Cooke SF, Bear MF. Visual recognition is heralded by shifts in local field potential oscillations and inhibitory networks in primary visual cortex Journal of Neuroscience. 2021 June 7
Kyrke-Smith M, Volk LJ, Cooke SF, Bear MF, Huganir RL, Shepherd JD. The Immediate Early Gene Arc Is Not Required For Hippocampal Long-Term Potentiation. Journal of Neuroscience. Epub 2021 April 8
Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao CC, Yu CJ, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES. Spatial Multiplexing of Flourescent Reporters for Imaging Signaling Network Dynamics. Cell. Epub 2020 Nov 23
Thomazeau A, Bosch M , Essayan-Perez S, Barnes SA, De Jesus-Cortes H & Bear MF. Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice Molecular Psychiatry. 2020 July 1
Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CJ, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator Neuron. 2020 Jun 25
McCamphill PK, Stoppel LJ, Senter RK, Lewis MC, Heynen AJ, Stoppel DC, Sridhar V, Collins KA, Shi X, Pan JQ, Madison J, Cottrell JR, Huber KM, Scolnick EM, Holson EB, Wagner FF, Bear MF. Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome Sci Transl Med. 2020 May 20
Lee Y, Han NE, Kim W, Kim JG, Lee IB, Choi SJ, Chun H, Seo M, Lee CJ, Koh HY, Kim JH, Baik JH, Bear MF, Choi SY, Yoon BJ. Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice Mol Cells. 2020 Apr 30
Fong MF, Finnie PS, Kim T, Thomazeau A, Kaplan ES, Cooke SF, Bear MF. Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity Cereb Cortex. 2020 Apr 14
Kim T, Chaloner FA, Cooke SF, Harnett MT, Bear MF. Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex Front Cell Neurosci. 2020 Jan 14
2010 – 2019
Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC. Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome Science Translational Medicine. 2019 May 29
Bear MF, Cooke SF, Giese KP, Kaang BK, Kennedy MB, Kim JI, Morris RGM, Park P. In memoriam: John Lisman – commentaries on CaMKII as a memory molecule. Molecular Brain. 2018 Dec 28
Howe JR, Bear, MF Golshani P, Klann, E, Lipton SA, Mucke L, Sahin M, and Silva AJ. The mouse as a model for neuropsychiatric drug development. Current Biology. 2018 Sep 10
Eavri R, Shepherd J, Welsh CA, Flanders GH, Bear MF, Nedivi E. Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline. J Neurosci. 2018 Sep 26.
Berry-Kravis EM, Lindemann L, Jonch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S. Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat Rev Drug Discov. 2017 Dec 8.
Duffy KR, Fong MF, Mitchell DE, Bear MF. Recovery from the anatomical effects of long-term monocular deprivation in cat lateral geniculate nucleus. J Comp Neurol. 2017 Oct 11. [Epub ahead of print]
Stoppel LJ, Kazdoba TM, Schaffler MD, Preza AR, Heynen A, Crawley JN, Bear MF. R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice. Neuropsychopharmacology. 2017 Oct 6. [Epub ahead of print]
Schecter RW, Maher EE, Welsh CA, Stevens B, Erisir A, Bear MF. Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1. J Neurosci. 2017 Sep 26. [Epub ahead of print]
Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shepherd JD. Arc restores juvenile plasticity in adult mouse visual cortex. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9182-9187
Berry-Kravis E, Hagerman R, Visootsak J, Budimirovic D, Kaufmann WE, Cherubini M, Zarevics P, Walton-Bowen K, Wang P, Bear MF, Carpenter RL. Arbaclofen in fragile X syndrome: results of phase 3 trials. J Neurodev Disord. 2017 Jun 12;9:3. eCollection 2017
Stoppel LJ, Auerbach BD, Senter RK, Preza AR, Lefkowitz RJ, Bear MF. β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Rep. 2017 Mar 21;18(12):2807-2814
Tao J, Wu H, Coronado AA, de Laittre E, Osterweil EK, Zhang Y, Bear MF. Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome. J Neurosci. 2016 Nov 23;36(47):11946-11958
Fong MF, Mitchell DE, Duffy KR, Bear MF. Rapid recovery from the effects of early moncular deprivation is enabled by temporary inactivation of the retinas. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14139-14144
Veenstra-VanderWeele J, Cook EH, King BH, Zarevics P, Cherubini M, Walton-Bowen K, Bear MF, Wang PP, Carptenter RL. Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trail. Neuropsychopharmacology. 2017 Jun;42(7):1390-1398
Kaplan ES, Cooke SF, Komorowski RW, Chubykin AA, Thomazeau A, Khibnik LA, Gavornik JP, Bear MF. Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity. eLife. 2016 Mar 4;5. pii: e11450
Prilutsky D, Kho AT, Palmer NP, Bhakar AL, Smedemark-Margulies N, Kong SW, Margulies DM, Bear MF, Kohane IS. Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures. Mol Autism. 2015 Dec 21;6:66
Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ. Convergence of Hippocampal Pathophysiology in Syngap(+/-) and Fmr1(-/y) Mice. J Neurosci. 2015 Nov 11;35(45):15073-81
Sidorov MS, Kaplan ES, Osterweil EK, Lindemann L, Bear MF. Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7
Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Hum Mol Genet. 2015 Nov 1;24(21):5977-84
Cooke SF, Bear MF. Visual recognition memory: a view from V1. Curr Opin Neurobiol. 2015 Jul 4;35:57-65
Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1. Nat Neurosci. 2015 Feb;18(2):262-71
Tian D, Stoppel LJ, Heynen AJ, Lindemann L, Jaeschke G, Mills AA, Bear MF. Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nat Neurosci. 2015 Feb;18(2):182-4
Sidorov MS, Krueger DD, Taylor M, Gisin E, Osterweil EK, Bear MF. Extinction of an instrumental response: A cognitive behavioral assay in Fmr1 knockout mice. Genes Brain Behav. 2014 Jun;13(5):451-8
Gavornik JP, Bear MF. Learned spatiotemporal sequence recognition and prediction in primary visual cortex. Nat Neurosci. 2014 May;17(5):732-7
Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Mol Autism. 2014 Feb 24;5(1):16
Cooke SF, Bear MF. How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130284
Erickson CA, Veenstra-Vanderweele JM, Melmed RD, McCracken JT, Ginsberg LD, Sikich L, Scahill L, Cherubini M, Zarevics P, Walton-Bowen K, Carpenter RL, Bear MF, Wang PP, King BH. STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study. J Autism Dev Disord. 2014 Apr;44(4):958-64
Lohith TG, Osterweil EK, Fujita M, Jenko KJ, Bear MF, Innis RB. Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Mol Autism. 2013 May 24;4(1):15
Sidorov MS, Auerbach BD, Bear MF. Fragile X mental retardation protein and synaptic plasticity. Mol Brain. 2013 Apr 8;6:15
Chubykin AA, Roach EB, Bear MF, Shuler MG. A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex. Neuron. 2013 Feb 20;77(4):723-35
Osterweil EK, Chuang SC, Chubykin AA, Sidorov M, Bianchi R, Wong RK, Bear MF. Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile x syndrome. Neuron. 2013 Jan 23;77(2):243-50
Osterweil EK, Kind PC, Bear MF. Lifting the Mood on Treating Fragile X. Biol Psychiatry. 2012 Dec 1;72(11):895-7
Cooper LN, Bear MF. The BCM theory of synapse modification at 30: interaction of theory with experiment. Nat Rev Neurosci. 2012 Nov;13(11):798-810
Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, … , Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM. Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen. Sci Transl Med. 2012 Sep 19;4(152):152ra128
Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen DV, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, Hagerman RJ. Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial. Sci Transl Med. 2012 Sep 19;4(152):152ra127
Michalon A, Sidorov M, Ballard TM, Ozmen L, Spooren W, Wettstein JG, Jaeschke G, Bear MF, Lindemann L. Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice. Neuron. 2012 Apr 12;74(1):49-56
Bhakar AL, Dölen G, Bear MF. The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci. 2012;35:417-43 Epub 2012 Apr 5
Zoghbi HY, Bear MF. Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). Review
Auerbach BD, Osterweil EK, Bear MF. Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature. 2011 Nov 23;480(7375):63-68
Rachmuth G, Shouval HZ, Bear MF, Poon CS. A biophysically-based neuromorphic model of spike rate- and timing-dependent plasticity. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1266-74
Cooke SF, Bear MF. Stimulus-Selective Response Plasticity in the Visual Cortex: An Assay for the Assessment of Pathophysiology and Treatment of Cognitive Impairment Associated with Psychiatric Disorders. Biol Psychiatry. 2012 Mar 15;71(6):487-95
Javitt DC, Schoepp D, Kalivas PW, Volkow ND, Zarate C, Merchant K, Bear MF, Umbricht D, Hajos M, Potter WZ, Lee CM. Translating glutamate: from pathophysiology to treatment. Sci Transl Med. 2011 Sep 28;3(102):102mr2
Shepherd JD, Bear MF. New views of Arc, a master regulator of synaptic plasticity. Nat Neurosci. 2011 Mar;14(3):279-84
Krueger DD, Osterweil EK, Chen SP, Tye LD, Bear MF. Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2587-92
Cooke SF, Bear MF. Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex. J Neurosci. 2010 Dec 1;30(48):16304-13
Krueger DD, Bear MF. Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome. Annu Rev Med. 2011;62:411-29
Osterweil EK, Krueger DD, Reinhold K, Bear MF. Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome. J Neurosci. 2010 Nov 17;30(46):15616-27
Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, … , Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM. Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment. Brain Res. 2011 Mar 22;1380:106-19
Coleman JE, Nahmani M, Gavornik JP, Haslinger R, Heynen AJ, Erisir A, Bear MF. Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex. J Neurosci. 2010 Jul 21;30(29):9670-82
Smith GB, Bear MF. Bidirectional ocular dominance plasticity of inhibitory networks: recent advances and unresolved questions. Front Cell Neurosci. 2010 Jun 17;4:21
Auerbach BD, Bear MF. Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis. J Neurophysiol. 2010 Aug;104(2):1047-51
Khibnik LA, Cho KK, Bear MF. Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex. Neuron. 2010 May 27;66(4):493-500
Dölen G, Carpenter RL, Ocain TD, Bear MF. Mechanism-based approaches to treating fragile X. Pharmacol Ther. 2010 Jul;127(1):78-93
McCurry CL, Shepherd JD, Tropea D, Wang KH, Bear MF, Sur M. Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation. Nat Neurosci. 2010 Apr;13(4):450-7
Cho KK, Bear MF. Promoting neurological recovery of function via metaplasticity. Future Neurol. 2010 Jan 1;5(1):21-26
Krueger DD, Osterweil EK, Bear MF. Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons. J Mol Neurosci. 2010 Sep;42(1):1-8
2000 – 2009
Morrow SA, Kaushik T, Zarevics P, Erlanger D, Bear MF, Munschauer FE, Benedict RH The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial J Neurol. 2009 Jul;256(7):1095-102
Wiig KA, Whitlock JR, Epstein MH, Carpenter RL, Bear MF The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation Neurobiol Learn Mem. 2009 Jul;92(1):106-13
Coleman JE, Law K, Bear MF Anatomical origins of ocular dominance in mouse primary visual cortex Neuroscience. 2009 Jun 30;161(2):561-71
Yoon BJ, Smith GB, Heynen AJ, Neve RL, Bear MF Essential role for a long-term depression mechanism in ocular dominance plasticity Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9860-5
Gavornik JP, Shuler MG, Loewenstein Y, Bear MF, Shouval HZ Learning reward timing in cortex through reward dependent expression of synaptic plasticity Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6826-31
Linden ML, Heynen AJ, Haslinger RH, Bear MF Thalamic activity that drives visual cortical plasticity Nat Neurosci. 2009 Apr;12(4):390-2
Cho KK, Khibnik L, Philpot BD, Bear MF The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5377-82
Smith GB, Heynen AJ, Bear MF Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67
Lee S, Kim W, Ham BJ, Chen W, Bear MF, Yoon BJ Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation Biochem Biophys Res Commun. 2008 Dec 19;377(3):930-4
Kelleher RJ 3rd, Bear MF The autistic neuron: troubled translation? Cell. 2008 Oct 31;135(3):401-6
Blais BS, Frenkel MY, Kuindersma SR, Muhammad R, Shouval HZ, Cooper LN, Bear MF Recovery from monocular deprivation using binocular deprivation J Neurophysiol. 2008 Oct;100(4):2217-24
Liu CH, Heynen AJ, Shuler MG, Bear MF Cannabinoid receptor blockade reveals parallel plasticity mechanisms in different layers of mouse visual cortex Neuron. 2008 May 8;58(3):340-5
Dölen G, Bear MF Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome J Physiol. 2008 Mar 15;586(6):1503-8
Hung AY, Futai K, Sala C, Valtschanoff JG, Ryu J, Woodworth MA, Kidd FL, Sung CC, Miyakawa T, Bear MF, Weinberg RJ, Sheng M Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1 J Neurosci. 2008 Feb 13;28(7):1697-708
Bear MF, Dölen G, Osterweil E, Nagarajan N Fragile X: translation in action Neuropsychopharmacology. 2008 Jan;33(1):84-7
Dölen G, Osterweil E, Rao BS, Smith GB, Auerbach BD, Chattarji S, Bear MF. Correction of fragile X syndrome in mice Neuron. 2007 Dec 20;56(6):955-62
Catania MV, D’Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? Mol Neurobiol. 2007 Jun;35(3):298-307
Philpot BD, Cho KK, Bear MF Obligatory Role of NR2A for Metaplasticity in Visual Cortex Neuron. 2007 Feb 15;53(4):495-502
Crozier RA, Wang Y, Liu CH, Bear MF Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1383-8
Whitlock JR, Heynen AJ, Shuler MG, Bear MF Learning induces long-term potentiation in the hippocampus Science. 2006 Aug 25;313(5790):1093-7
Morishita W, Lu W, Smith GB, Nicoll RA, Bear MF, Malenka RC Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression Neuropharmacology, 2007 Jan; 52(1): 71-6
Chen WS, Bear MF Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex Neuropharmacology 2007 Jan; 52(1): 200-14
Frenkel MY, Sawtell NB, Diogo AC, Yoon B, Neve RL, Bear MF Instructive effect of visual experience in mouse visual cortex Neuron. 2006 Aug 3;51(3):339-49
Iny K, Heynen AJ, Sklar E, Bear MF Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats J Neurosci. 2006 Jul 12;26(28):7368-74
Rittenhouse CD, Siegler BA, Voelker CA, Shouval HZ, Paradiso MA, Bear MF The Stimulus for Rapid Ocular Dominance Plasticity in Visual Cortex J Neurophysiol. 2006 May; 95(5): 2947-50
Shuler MG, Bear MF Reward timing in the primary visual cortex Science. 2006 Mar 17;311(5767):1606-9
Bear MF Therapeutic implications of the mGluR theory of fragile X mental retardation Genes Brain Behav. 2005 Aug;4(6):393-8
Dölen G, Bear MF Courting a cure for fragile X Neuron. 2005 Mar 3;45(5):642-4
Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression J Biol Chem. 2005 Apr 29;280(17):16962-8
Frenkel MY, Bear MF How monocular deprivation shifts ocular dominance in visual cortex of young mice Neuron. 2004 Dec 16;44(6):917-23
Malenka RC, Bear MF LTP and LTD: an embarrassment of riches Neuron. 2004 Sep 30;44(1):5-21
Wallace W, Bear MF A morphological correlate of synaptic scaling in visual cortex J. Neurosci. 2004 Aug; 24(31):6928-6938
Bear MF, Huber KM, Warren ST The mGluR theory of fragile x mental retardation Trends in Neuroscience 2004 Jul; 27(7): 370-377
Nahm WK, Philpot BD, Adams MM, Badiavas EV, Zhou LH, Butmarc J, Bear MF, Falanga V Significance of N-methyl-D-(NMDA) receptor-mediated signaling in human keratinocytes J. Cellular Physiology 2004 Aug; 200(2):309-17
Gallagher SM, Daly CA, Bear MF, Huber KM Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1 J Neurosci. 2004 May 19; 24(20):4859-64
Jackson JD, Yezzi AJ, Wallace W, Bear MF Segmentation of coarse and fine scale features using multi-scale diffusion and Mumford-Shah Lecture Notes in Computer Science. 2003;2695:615-624
Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF, Scott JD Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression Neuron. 2003 Oct 30;40(3):595-607
Heynen AJ, Yoon B-J, Liu C-H, Chung HJ, Huganir RL, Bear MF Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation Nat Neurosci. 2003 Aug;6(8):854-862
Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex Neuron. 2003 Jun 19;38(6):977-85
Bear MF Bidirectional synaptic plasticity: from theory to reality Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):649-55
Shouval HZ, Bear MF, Cooper LN A unified model of NMDA receptor-dependent bidirectional synaptic plasticity Proc Natl Acad Sci U S A. 2002 Jul 22
Huber KM, Gallagher SM, Warren ST, Bear MF Altered synaptic plasticity in a mouse model of fragile X mental retardation Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
Philpot BD, Bear MF Synaptic plasticity in an altered state Neuron. 2002 Feb 28;33(5):665-7
Heynen AJ, Bear MF Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo J Neurosci. 2001 Dec 15;21(24):9801-13
Wells DG, Dong X, Quinlan EM, Huang YS, Bear MF, Richter JD, Fallon JR A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons J Neurosci. 2001 Dec 15;21(24):9541-8
Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory Cell. 2001 Nov 30;107(5):617-29
Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, Bear MF Internalization of ionotropic glutamate receptors in response to mGluR activation Nat Neurosci. 2001 Nov;4(11):1079-85
Philpot BD, Weisberg MP, Ramos MS, Sawtell NB, Tang YP, Tsien JZ, Bear MF Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex Neuropharmacology. 2001 Nov;41(6):762-70
Abraham WC, Mason-Parker SE, Bear MF, Webb S, Tate WP Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10924-9
Rozas C, Frank H, Heynen AJ, Morales B, Bear MF, Kirkwood A Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex J Neurosci. 2001 Sep 1;21(17):6791-801
Huber KM, Roder JC, Bear MF Chemical induction of mGluR5- and protein synthesis–dependent long-term depression in hippocampal area CA1 J Neurophysiol. 2001 Jul;86(1):321-5
Philpot BD, Sekhar AK, Shouval HZ, Bear MF Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex Neuron. 2001 Jan;29(1):157-69. Shouval HZ, Bear MF, Cooper LN
Heynen AJ, Quinlan EM, Bae DC, Bear MF Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo Neuron. 2000 Nov;28(2):527-36
Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity Nature. 2000 Jun 22;405(6789):955-9
Huber KM, Kayser MS, Bear MF Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression Science. 2000 May 19;288(5469):1254-7
1990-1999
Sawtell NB, Huber KM, Roder JC, Bear MF Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors J Neurophysiol. 1999 Dec;82(6):3594-7
Quinlan EM, Olstein DH, Bear MF Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12876-80
Bear MF, Rittenhouse CD Molecular basis for induction of ocular dominance plasticity J Neurobiol. 1999 Oct;41(1):83-91
Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex Cell. 1999 Sep 17;98(6):739-55
Bear MF Homosynaptic long-term depression: a mechanism for memory? Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9457-8
Quinlan EM, Philpot BD, Huganir RL, Bear MF Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo Nat Neurosci. 1999 Apr;2(4):352-7
Taubenfeld SM, Wiig KA, Bear MF, Alberini CM A molecular correlate of memory and amnesia in the hippocampus Nat Neurosci. 1999 Apr;2(4):309-10
Kirkwood A, Rozas C, Kirkwood J, Perez F, Bear MF Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine J Neurosci. 1999 Mar 1;19(5):1599-609
Rittenhouse CD, Shouval HZ, Paradiso MA, Bear MF Monocular deprivation induces homosynaptic long-term depression in visual cortex Nature. 1999 Jan 28;397(6717):347-50
Kameyama K, Lee HK, Bear MF, Huganir RL Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression Neuron. 1998 Nov;21(5):1163-75
Lee HK, Kameyama K, Huganir RL, Bear MF NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus Neuron. 1998 Nov;21(5):1151-62
Huber KM, Sawtell NB, Bear MF Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex Neuropharmacology. 1998 Apr-May;37(4-5):571-9
Huber KM, Sawtell NB, Bear MF Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex J Neurosci. 1998 Jan 1;18(1):1-9
Kirkwood A, Silva A, Bear MF Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3380-3
Bear MF How do memories leave their mark? Nature. 1997 Feb 6;385(6616):481-2
Bear MF A synaptic basis for memory storage in the cerebral cortex Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13453-9
Aizenman CD, Kirkwood A, Bear MF A current source density analysis of evoked responses in slices of adult rat visual cortex: implications for the regulation of long-term potentiation Cereb Cortex. 1996 Nov-Dec;6(6):751-8
Kirkwood A, Rioult MC, Bear MF Experience-dependent modification of synaptic plasticity in visual cortex Nature. 1996 Jun 6;381(6582):526-8
Heynen AJ, Abraham WC, Bear MF Bidirectional modification of CA1 synapses in the adult hippocampus in vivo Nature. 1996 May 9;381(6578):163-6
Abraham WC, Bear MF Metaplasticity: the plasticity of synaptic plasticity Trends Neurosci. 1996 Apr;19(4):126-30
Bear MF Progress in understanding NMDA-receptor-dependent synaptic plasticity in the visual cortex J Physiol Paris. 1996;90(3-4):223-7
Bear MF NMDA-receptor-dependent synaptic plasticity in the visual cortex Prog Brain Res. 1996;108:205-18
Bear MF, Abraham WC Long-term depression in hippocampus Annu Rev Neurosci. 1996;19:437-62
Wiig KA, Cooper LN, Bear MF Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat Learn Mem. 1996 Nov-Dec;3(4):313-25
Selig DK, Lee HK, Bear MF, Malenka RC Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation J Neurophysiol. 1995 Sep;74(3):1075-82
Bear MF Mechanism for a sliding synaptic modification threshold Neuron. 1995 Jul;15(1):1-4
Kirkwood A, Lee HK, Bear MF Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience Nature. 1995 May 25;375 (6529):328-31
Kirkwood A, Bear MF Elementary forms of synaptic plasticity in the visual cortex Biol Res. 1995;28(1):73-80
Bear MF, Malenka RC Synaptic plasticity: LTP and LTD Curr Opin Neurobiol. 1994 Jun;4(3):389-99
Kirkwood A, Bear MF Homosynaptic long-term depression in the visual cortex J Neurosci. 1994 May;14(5 Pt 2):3404-12
Gold JI, Bear MF A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3941-5
Kirkwood A, Bear MF Hebbian synapses in visual cortex J Neurosci. 1994 Mar;14(3 Pt 2):1634-45
Law CC, Bear MF, Cooper LN Role of the visual environment in the formation of receptive fields according to the BCM theory Prog Brain Res. 1994;102:287-301
Dudek SM, Bear MF Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus J Neurosci. 1993 Jul;13(7):2910-8
Kirkwood A, Dudek SM, Gold JT, Aizenman CD, Bear MF Common forms of synaptic plasticity in the hippocampus and neocortex in vitro Science. 1993 Jun 4;260(5113):1518-21
Bear MF, Kirkwood A Neocortical long-term potentiation Curr Opin Neurobiol. 1993 Apr;3(2):197-202
Bohner AP, Dudek SM, Bear MF Effects of N-methyl-D-aspartate on quisqualate-stimulated phosphoinositide hydrolysis in slices of kitten striate cortex Brain Res. 1992 Oct 23;594(1):146-9
Dudek SM, Bear MF Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade Proc Natl Acad Sci U S A. 1992 May 15;89(10):4363-7
Bear MF, Press WA, Connors BW Long-term potentiation in slices of kitten visual cortex and the effects of NMDA receptor blockade J Neurophysiol. 1992 Apr;67(4):841-51
Clothiaux EE, Bear MF, Cooper LN Synaptic plasticity in visual cortex: comparison of theory with experiment J Neurophysiol. 1991 Nov;66(5):1785-804
Alkon DL, Amaral DG, Bear MF, Black J, Carew TJ, Cohen NJ, Disterhoft JF, Eichenbaum H, et al. Learning and memory. FESN Study Group Brain Res Brain Res Rev. 1991 May-Aug;16(2):193-220
Reynolds IJ, Bear MF Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex Exp Brain Res. 1991;85(3):611-5
Bear MF, Dudek SM Stimulation of phosphoinositide turnover by excitatory amino acids: Pharmacology, development, and role in visual cortical plasticity Ann N Y Acad Sci. 1991;627:42-56
Bear MF, Colman H Binocular competition in the control of geniculate cell size depends upon visual cortical N-methyl-D-aspartate receptor activation Proc Natl Acad Sci U S A. 1990 Dec;87(23):9246-9
Barstad KE, Bear MF Basal forebrain projections to somatosensory cortex in the cat J Neurophysiol. 1990 Oct;64(4):1223-32
Juliano SL, Ma W, Bear MF, Eslin D Cholinergic manipulation alters stimulus-evoked metabolic activity in cat somatosensory cortex J Comp Neurol. 1990 Jul 1;297(1):106-20
Bear MF, Kleinschmidt A, Gu QA, Singer W Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist J Neurosci. 1990 Mar;10(3):909-25
Feldman D, Sherin JE, Press WA, Bear MF N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro Exp Brain Res. 1990;80(2):252-9
1980 – 1989
Dudek SM, Bear MF A biochemical correlate of the critical period for synaptic modification in the visual cortex Science. 1989 Nov 3;246(4930):673-5
Gu QA, Bear MF, Singer W Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation Brain Res Dev Brain Res. 1989 Jun 1;47(2):281-8
Neve RL, Bear MF Visual experience regulates gene expression in the developing striate cortex Proc Natl Acad Sci U S A. 1989 Jun;86(12):4781-4
Dudek SM, Bowen WD, Bear MF Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes Brain Res Dev Brain Res. 1989 May 1;47(1):123-8
Bear MF, Kleinschmidt A, Singer W Experience-dependent modifications of kitten striate cortex are not prevented by thalamic lesions that include the intralaminar nuclei Exp Brain Res. 1988;70(3):627-31
Kleinschmidt A, Bear MF, Singer W Blockade of “NMDA” receptors disrupts experience-dependent plasticity of kitten striate cortex Science. 1987 Oct 16;238(4825):355-8
Bear MF, Cooper LN, Ebner FF A physiological basis for a theory of synapse modification Science. 1987 Jul 3;237(4810):42-8
Bear MF, Singer W Modulation of visual cortical plasticity by acetylcholine and noradrenaline Nature. 1986 Mar 13-19;320(6058):172-6
Bear MF, Carnes KM, Ebner FF Postnatal changes in the distribution of acetylcholinesterase in kitten striate cortex J Comp Neurol. 1985 Jul 22;237(4):519-32
Bear MF, Schmechel DE, Ebner FF Glutamic acid decarboxylase in the striate cortex of normal and monocularly deprived kittens J Neurosci. 1985 May;5(5):1262-75
Hohmann CF, Bear MF, Ebner FF Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain Brain Res. 1985 Apr 29;333(1):165-8
Bear MF, Carnes KM, Ebner FF An investigation of cholinergic circuitry in cat striate cortex using acetylcholinesterase histochemistry J Comp Neurol. 1985 Apr 22;234(4):411-30
Haycock DA, Bear MF The stability of 6-hydroxydopamine under minipump conditions Exp Brain Res. 1984;56(1):183-6
Bear MF, Ebner FF Somatostatin-like immunoreactivity in the forebrain of Pseudemys turtles Neuroscience. 1983 Jun; 9(2):297-307
Bear MF, Paradiso MA, Schwartz M, Nelson SB, Carnes KM, Daniels JD Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity Nature. 1983 Mar 17-23;302(5905):245-7
Bear MF, Daniels JD The plastic response to monocular deprivation persists in kitten visual cortex after chronic depletion of norepinephrine J Neurosci. 1983 Feb;3(2):407-16
Carey RG, Bear MF, Diamond IT The laminar organization of the reciprocal projections between the claustrum and striate cortex in the tree shrew, Tupaia gli Brain Res. 1980 Feb 17;184(1):193-8